thestar.com.my

  Search:       
   Home | Health
  More Channels
  News
  Business
  Sports
  Entertainment
  Lifestyle
  Technology
  Education
  Classifieds
  Directory
  e-Cards
  Member
  30-Day Archives
  Chat
  Clubs
  Contests
  Games
  WebMail
  Extras
  Property
  Motoring
  Purple Sofa
  Comics
  AudioFile
  Maritime
  Jobs
  CyberKuali
  Clove
  Weather
  Specials
  Online exclusives
  Columnists
  Millennium Markers
  Penang Story
  Honours lists

Sunday April 24, 2005

Regenerating own cells

INJURIES to the cartilage are problematic primarily because cartilage cannot self-repair. Such injuries can result in degenerative changes and osteoarthritis if left untreated. 

Autologous chondrocyte implantation (ACI) 

This is a clinically proven application of tissue engineering for the treatment of full thickness articular cartilage defects. Basically it involves regenerating cartilage using the patientís own (autologous) cartilage cells (chondrocytes). 

The technique was developed in Europe, USA and Australasia and has proven clinical efficacy and long-term durability. 

The resultant cartilage exhibits similar physiological and biomechanical properties as the original cartilage, and the patient can return to pre-injury activities. 

In the long-term, the procedure eliminates the need for further surgical intervention and joint replacement. 

Periosteum covered ACI (PACI) 

This is a technique where the cells are implanted beneath live autologous periosteum: 

Stage 1: Cartiage biospy is taken from patient.
Stage 2: Chondrocytes (cartilage cells) are isolated and multiplied in sterile culture laboratory (four weeks).
Stage 3
Patient selection 

The technique is suitable for:
1. Cartilage damage caused by direct injury (for example sports injury)
2. Aged 15 - 55 years old
3. Lesion sizes ranging from 1 - 10cm2
4. Multiple lesions acceptable
5. Most lesions of the knee and ankle(potential to extend to shoulder, hip and elbow)
It is not suitable for:
1. Widespread cartilage damage
2. Osteoarthritis (slow degeneration)
3. Rheumatoid arthritis (inflammatory disease)
4. Medication likely to compromise cartilage proliferation (steroids or chemotherapy). 

Related stories
The price method
A worldwide joint declaration
More than a simple hinge


Printer Friendly | Email This



thestar.com.my Logo    More @ The Star Online:
   NewsBusinessSportsEntertainmentLifestyleTechnologyEducationArchives
   ClassifiedsDirectorye-CardsMotoringPropertyJobsKualiSitemap

Copyright © 1995-2005 Star Publications (Malaysia) Bhd (Co No 10894-D)
Managed by I.Star.